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. 2021 Oct 15;246(19):2128–2135. doi: 10.1177/15353702211032549

Figure 3.

Figure 3.

Expression of Type-A GABA receptor subunit genes in the pediatric brain cancer medulloblastoma. Shown is a heatmap across four molecular subgroups of medulloblastoma (Top row: WNT, SHH, Group 3, and Group 4) and subtypes within each subgroup (lower row), where color scaling indicates low (green) to high (red) expression. In Group 3 patient tumors (yellow), there is enhanced expression of GABRA5, which codes for the α-5 subunit. In contrast, in WNT patient tumors (blue), there is enhanced expression of a different set of GABR genes. While in SHH patient tumors (red) there is a subset of patients (purple) that share an enhanced expression of yet a different set of GABR genes. Figure adapted from Kallay, et al. Modulating native GABAA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death. J Neurooncol 2019;142:411–422.