Table 1.
Baseline characteristics of AIDS Linked to the IntraVenous Experience participants by index frailty transition statea.
| Stable nonfrail N = 1081 | Frail to nonfrail N = 101 | Nonfrail to frail N = 113 | Stable frail N = 58 | |
|---|---|---|---|---|
| All participants | ||||
| Age, mean (SD) (years) | 47.2 (7.8) | 48.8 (9) | 48.5 (7.5) | 50.8 (7.0) |
| Female | 335 (31.0) | 42 (41.6) | 49 (43.4) | 26 (44.8) |
| African American | 955 (88.3) | 93 (92.1) | 99 (87.6) | 53 (91.4) |
| ≥High school education | 462 (42.9) | 46 (45.5) | 44 (38.9) | 14 (24.1) |
| Employed | 276 (25.6) | 21 (20.8) | 14 (12.4) | 7 (12.1) |
| No hazardous alcohol useb | 838 (77.5) | 78 (77.2) | 82 (72.6) | 41 (70.7) |
| Recent injection drug use | 473 (43.8) | 45 (44.6) | 42 (37.2) | 24 (41.4) |
| Recent tobacco use | 884 (82.0) | 90 (89.1) | 95 (84.1) | 50 (86.2) |
| Prescription drug abuse | 107 (9.9) | 15 (14.9) | 19 (16.8) | 11 (19.0) |
| Any noninjection drug use | 489 (45.2) | 51 (50.5) | 55 (48.7) | 29 (50.0) |
| No depressive symptomsc | 868 (80.3) | 64 (63.4) | 82 (72.6) | 30 (51.7) |
| No of comorbid conditionsd | ||||
| ≥3 | 85 (8.0) | 15 (15.2) | 14 (13.0) | 14 (26.9) |
| 2 | 163 (15.4) | 16 (16.2) | 18 (16.7) | 10 (19.2) |
| 1 | 352 (33.2) | 36 (36.4) | 42 (38.9) | 16 (30.8) |
| 0 | 461 (43.5) | 32 (32.3) | 34 (31.5) | 12 (23.1) |
| HIV seropositive | 348 (32.2) | 32 (31.7) | 42 (37.2) | 25 (43.1) |
| HIV-infected participants | ||||
| CD4+ cell count (cells/μl), median (IQR) | 359 (213, 591) | 450 (280, 784) | 371 (191, 691) | 360 (262, 611) |
| HIV RNA, median (IQR), log10 copies/ml | 2.46 (1.60, 4.36) | 2.21 (1.60, 4.47) | 2.02 (1.60, 4.20) | 3.43 (1.76, 4.31) |
| Median CD4+ nadir (IQR) | 143 (57, 260) | 230 (71, 322) | 131 (52, 248) | 226 (87, 280) |
| Prior AIDS diagnosis | 61 (5.6) | 9 (8.9) | 12 (10.6) | 8 (13.8) |
IQR, interquartile range; SD, standard deviation.
Data are number (%) of participants prior to transition, unless otherwise indicated; behavioral variables reflect characteristics within the prior 6 months, unless otherwise indicated; nonfrail participants had a frailty score of 0–2; frail participants had a frailty score of 3–5.
No hazardous alcohol use, score of <8 on the Alcohol Use Disorders Identification Test.
No depressive symptoms, score <21 on the Center for Epidemiological Studies Depression Scale.
Diabetes, hypertension, cerebrovascular accident, cardiovascular disease, renal disease, chronic obstructive pulmonary disease, cancer, obesity, liver disease.