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. 2021 Oct 18;13:166. doi: 10.1186/s13073-021-00981-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — CDC7 inhibitor synergies with AZD6738 or MK-8776 in HCC cells. a, b Short-term colony formation assays showing synergistic response to XL413 (10 μM) combined with AZD6738 or MK-8776 in three HCC cell lines (resistant to ATR or CHK1 inhibitors: Huh6, PLC/PRF/5 and SNU449) after 4–5 days treatment. c Quantification of CellTiter-Blue viability assays of Huh6, PLC/PRF/5, and SNU449 cells treated with XL413, AZD6738, MK-8776 or the combination at the indicated concentrations. d, e Representative images of PLC/PRF/5 and SNU449 cells treated with XL413, AZD6738, MK-8776 or the indicated combinations for 96 h in the presence of a green fluorescent caspase-3/7 activatable dye. The proportion of cells containing caspase-3/7 staining is shown