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. 2021 Oct 18;13:166. doi: 10.1186/s13073-021-00981-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Combined CDC7 and ATR-CHK1 inhibition leads to defective cell cycle of HCC cells. a, b Representative live cell images of PLC/PRF/5 and SNU449 cells expressing GFP-Histone 2B. Cells treated with XL413 (10 μM), AZD6738 (1.25 μM), MK-8776 (2.5 μM) or the indicated combinations were monitored by time-lapse microscopy. c Quantification of mitosis duration based on time-lapse microscopy analysis (n > 30 cells per cell line and condition). d Percentages of cell fates of PLC/PRF/5 and SNU449 cells in the absence or presence of XL413 (10 μM), AZD6738 (1.25 μM), MK-8776 (2.5 μM) or the indicated combination were analyzed using time-lapse microscopy (n = 50 cells per group). **P < 0.01 and ***P < 0.001