Table 1.

The roles of GAPs in RCD

GAPs	RCD	Effect	Target	Associated physiology and pathology	References
p120RasGAP (RASA1)	Apoptosis	up/down	RAS, N-terminal fragment	Hepatocellular carcinoma, capillary malformation-arteriovenous malformation	[16, 28]
RGS3	Apoptosis	up	MEK/ERK	Hepatocellular carcinoma	[19]
STARD13	Apoptosis	up	Bax	Breast cancer	[20]
DLC1	Apoptosis	up	NF-кB	Angiosarcoma	[21]
DAB2IP	Apoptosis	up	STAT3, β-amyloid	Prostate cancer, Alzheimer's disease	[23, 30]
RACGAP1	Apoptosis	down	Hippo signaling pathway	Hepatocellular carcinoma	[24]
RGS5	Apoptosis	down	JNK1/2 and p38 signaling pathways	Cardiomyocytes	[29]
TBC1D17	Apoptosis	down	Rab12	Optic neuropathy	[31]
OATL1	Autophagy	down	RAB33B	Autophagosome maturation	[45]
TSC1/2	Autophagy	up	Rheb-mTORC1-ULK1 signaling pathway	Tuberous sclerosis complex	[51]
RalGAP	Autophagy	down/up	RalB, mTORC1	Autophagosome formation	[47, 53]
DAB2IP	Autophagy	down	Wnt/β-catenin signaling pathway, mTOR-S6K pathway	Glioblastoma, prostate cancer	[54, 55, 57]
SIPA1L2	Autophagy	down	TrkB/LC3b	Neurotransmitter liberation	[58]
TBC1D5	Autophagy	down	Rab7a	Neurodegenerative diseases, glucose uptake	[61, 67]
TBC1D15	Autophagy	down	RAB7	Neurodegenerative diseases	[62, 63]
SGSM3/RABGAP5	Autophagy	down	RAB5	Ehrlichia infection	[64]
TBC1D10A	Autophagy	down	Rab35-NDP52	Autophagosome formation	[65]
TBC1D20	Autophagy	down	RAB1B	Warburg Micro syndrome 4	[66]
TBC1D2	Ferroptosis	down	RAB7A	Lipid degradation	[75]
YopE	Pyroptosis	up	Rho GTPase	Yersinia infection	[79]
p190A RhoGAP	Entosis	up/down	Rho-ROCK signaling	Cell adhesion and cytoskeletal rearrangement	[84]
NF1	Mitotic catastrophe	up	RAS	Mitotic arrest	[89]
p190RhoGAP	Mitotic catastrophe	up	RhoA	Neoplastic multinucleation	[90]
RanGAP1	Mitotic catastrophe	up	Mitotic localization	Abnormal spindle formation	[91]
GIT1	Methuosis	up/down	Arf6	Vacuoles formation	[94–96]