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. 2021 Oct 18;21:550. doi: 10.1186/s12935-021-02253-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — LINC00337 is raised in lung adenocarcinoma tissues and cells, and is significantly present in the cell cytoplasm. A Volcano plot of TCGA + GTEx database, and LINC00337 is increased in lung adenocarcinoma. B The RNA level of LINC00337 in lung adenocarcinoma samples (from TCGA database) and normal samples (from GTEx database). C LINC00337 expression in 46 pairs of lung adenocarcinoma tissues and para-tumor tissues from our data. D LINC00337 expression in lung adenocarcinoma PC-9, H1373, HCC827, and A549 cell lines and normal human lung epithelial BEAS2B cell line. E Kaplan–Meier curves of overall survival from TCGA database. The median expression level of LINC00337 was used as the cutoff. F Localization of LINC00337 by nucleocytoplasmic separation experiment. Data represent the mean ± SD; *P < 0.05, ** P < 0.01, ***P < 0.001