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. 2021 Oct 18;16:105. doi: 10.1186/s13020-021-00517-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Effects of Scu administration on primary cortical neurons post OGD. a The dose response curve showed the significant variation from log (EC50) (− 2) to log (EC50) 2. b, c Stimulation ratio comparison among the Scu groups of different concentrations, normal group, and OGD group. There was a statistically significant difference in Scu 3 μM group and Scu 10 μM group compared with the normal group and OGD group. d Cell number among the normal, OGD, Scu 1 μM, Scu 3 μM and Scu 10 μM groups. e TUNEL/DAPI results showed cell apoptosis in the normal, OGD, OGD + Scu 1 μM, OGD + Scu 3 μM, OGD + Scu 10 μM and OGD + Scu 15 μM groups. f Immunofluorescence staining results of Tuj1 in the normal, OGD, Control and OGD + Scu 3 μM groups. Normal only cell culture group, OGD Oxygen–glucose deprivation, Control OGD + DMSO group, Scu Scutellarin, TUNEL Terminal-deoxynucleoitidyl Transferase Mediated Nick End Labeling, DAPI 4ʹ,6-diamidino-2-phenylindole, a fluorescent dye used in nucleic acid stain. *p < 0.05, scale bar = 50 μm, n = 3/group