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. 2021 Oct 18;16:105. doi: 10.1186/s13020-021-00517-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Role of GAP43 in long–term neurological function of Scu-treated HI rats. a Zea-longa scores of HI rats in the sham, GAP43^+/+, GAP43^+/+ + Scu, GAP43^−/− + Scu groups. b The latency to target in these four groups in the Morris water maze test, respectively. c–e The number of crossing original location of platform and the distance and time for crossing the original location of quadrant in the GAP43^+/+, GAP43^+/+ + HI, GAP43^+/+ + HI + Scu, GAP43^−/− + HI + Scu groups. f, i The stand-up times and the number of grooming in the open field test in these groups. g, h The latent period and total distance in the open field test among the four groups. j, k The proportion of food arm entries and total distance finding the food arm of Y-maze in the above-mentioned groups. l The longest residence time in Rotarod test among these groups. GAP43^+/+ wild-type rats; GAP43^−/− GAP43 knockout, HI hypoxia–ischemia, Scu Scutellarin, d days. *p < 0.05 vs. GAP43^+/+ + HI + Scu, **p < 0.01 vs. GAP43^+/+ + HI + Scu, ***p < 0.001 vs. GAP43^+/+ + HI + Scu, n = 5/group