Fig. 6.

The interaction among GAP43, PTN, STAT3 and JAK2. a GeneMANIA analysis on genes which GAP43 were co-expressed and co-localized. b The mutual relation among GAP43, PTN, JAK2 and STAT3. The backward slash represents co-expression. The contiguous arrow represents co-localization. The separate arrow represents prediction. The solid line represents shared protein domains. c–e The relative expression changes of PTN, STAT3 and JAK2 after GAP43 interference in the normal, Reagent, NC, GAP43i groups, respectively. NC negative control, GAP43i GAP43 interference. Data are presented as the mean ± SD. *** p < 0.001, n = 3/group