Table 2.
Adjustment of vascular risk factors over time and comparison of study groups; n = 513
| CEA | CAS | BMT | total | p1 | p2 | |
|---|---|---|---|---|---|---|
| Systolic BP D0 (median [IQR])□ | 147 (131; 160) | 145 (130; 162) | 150 (133; 160) | 146 (130; 160) | 0.7317◊ | |
| Diastolic BP D0 (median [IQR])□ | 80 (72; 88) | 80 (74; 90) | 80 (75; 89) | 80 (73; 89) | 0.5734◊ | |
| Systolic BP D30 (median [IQR]) | 142 (131; 160) | 140 (130; 154) | 141 (130; 160) | 142 (130; 160) | 0.2178◊ | 0.0005⌂* |
| Diastolic BP D30 (median [IQR]) | 80 (71; 85) | 80 (71; 87) | 80 (70; 89) | 80 (71; 86) | 0.9233◊ | 0.0160⌂* |
| Systolic BP M6 (median [IQR]) | 144.5 (130; 158) | 140 (130; 159) | 140 (128; 160) | 141 (130; 159) | 0.6510◊ | < 0.0001⌂* |
| Diastolic BP M6 (median [IQR]) | 80 (70; 87) | 80 (74; 86) | 80 (72; 86) | 80 (72; 86) | 0.4862◊ | 0.0035⌂* |
| Systolic BP A1 (median [IQR]) | 142.5 (130; 158) | 140 (130; 156) | 140 (130; 150) | 140 (130; 157) | 0.6320◊ | < 0.0001⌂* |
| Diastolic BP A1 (median [IQR]) | 80 (70.5; 85) | 80 (72; 85) | 80 (70; 85) | 80 (71; 85) | 0.8059◊ | 0.0001⌂* |
| Blood glucose (median [IQR]) D0□ | 103.5 (92; 121) | 104 (93; 125) | 104 (92; 119) | 104 (92.5; 122) | 0.8918◊ | |
| Blood glucose (median [IQR]) D30 | 110.5 (95; 131) | 105 (95; 125) | 101 (92; 121) | 107 (94; 125) | 0.2776◊ | 0.1054⌂ |
| Blood glucose (median [IQR]) M6 | 108 (96; 125) | 103 (94; 126) | 101 (92.5; 123) | 104 (94; 125) | 0.3761◊ | 0.8950⌂ |
| Blood glucose (median [IQR]) A1 | 105 (93; 124) | 105 (93; 124) | 105.5 (96.5; 127) | 105 (94; 124.5) | 0.6192◊ | 0.2191⌂ |
| HbA1c (in %; median [IQR]) D0□ | 6 (5.7; 6.45) | 6 (5.7; 6.6) | 5.9 (5.55; 6.75) | 6 (5.7; 6.5) | 0.5940◊ | |
| HbA1c (in %; median [IQR]) D30 | 5.9 (5.6; 6.4) | 5.9 (5.6; 6.4) | 5.9 (5.5; 6.6) | 5.9 (5.6; 6.4) | 0.7903◊ | 0.0025⌂* |
| HbA1c (in %; median [IQR]) M6 | 6.1 (5.7; 6.6) | 6.0 (5.7; 6.4) | 5.9 (5.5; 6.7) | 6.0 (5.7; 6.5) | 0.4636◊ | 0.7925⌂ |
| HbA1c (in %; median [IQR]) A1 | 6.0 (5.5; 6.5) | 5.9 (5.7; 6.5) | 6.0 (5.5; 6.7) | 6.0 (5.6; 6.5) | 0.9039◊ | 0.5419⌂ |
| Cholesterol (median [IQR]) D0□ | 181 (153; 209) | 173.5 (152; 200) | 169.5 (146.5; 192.5) | 174 (151; 203) | 0.2619◊ | |
| Cholesterol (median [IQR]) D30 | 175 (149; 207) | 168 (150.5; 193.5) | 159 (142; 191) | 168.5 (148; 196) | 0.0744◊ | 0.0025⌂* |
| Cholesterol (median [IQR]) M6 | 176 (149; 199) | 170 (150; 194) | 161 (143; 175) | 168 (147; 194) | 0.0056◊* | 0.0091⌂* |
| Cholesterol (median [IQR]) A1 | 174 (150; 202) | 167 (143; 198) | 164 (140; 184) | 167 (146; 194) | 0.0385◊* | 0.0017⌂* |
| LDL-Cholesterol (median [IQR]) D0□ | 105 (81; 130) | 98.5 (80; 126) | 97 (80; 117) | 99 (80; 123.5) | 0.3559◊ | |
| LDL-Cholesterol (median [IQR]) D30 | 98 (78; 125) | 91 (76; 114) | 88 (72; 106) | 91 (76; 116) | 0.0985◊ | 0.0001⌂* |
| LDL-Cholesterol (median [IQR]) M6 | 98 (75; 119) | 95 (80; 115) | 87 (72; 103) | 92 (75; 113) | 0.0286◊* | 0.0006⌂* |
| LDL-Cholesterol (median [IQR]) A1 | 98 (78; 118) | 93 (72; 116) | 87 (69; 108) | 93 (73; 116) | 0.1164◊ | 0.0001⌂* |
| HDL-Cholesterol (median [IQR]) D0□ | 48 (40; 62) | 49 (40; 56.5) | 49 (41.5; 57.5) | 49 (41; 58) | 0.8799◊ | |
| HDL-Cholesterol (median [IQR]) D30 | 50 (40; 60) | 48 (40; 60) | 50 (41; 59) | 49 (41; 60) | 0.6703◊ | 0.8535⌂ |
| HDL-Cholesterol (median [IQR]) M6 | 49 (40; 60) | 49 (41; 60) | 48 (41; 56) | 49 (41; 59) | 0.8393◊ | 0.6249⌂ |
| HDL-Cholesterol (median [IQR]) A1 | 48 (41; 59.5) | 49 (40; 58.5) | 49.5 (41.5; 60) | 49 (41; 59.5) | 0.9204◊ | 0.0592⌂ |
| Triglycerides (median [IQR]) D0□ | 131 (98; 182.5) | 128.5 (92; 184) | 120 (91; 181) | 126.5 (94; 182) | 0.6626◊ | |
| Triglycerides (median [IQR]) D30 | 121 (92, 207) | 114 (87; 174) | 121 (87; 181) | 119 (88; 181) | 0.5671◊ | 0.0893⌂ |
| Triglycerides (median [IQR]) M6 | 133.5 (94; 192) | 124 (90; 164) | 107 (78; 143) | 122.5 (89; 173.5) | 0.0123◊* | 0.0581⌂ |
| Triglycerides (median [IQR]) A1 | 136 (97; 192) | 112.5 (88; 182) | 132 (91; 173) | 127 (91; 183) | 0.0920◊ | 0.5763⌂ |
| BMI D0 (median [IQR])□ | 27 (25; 30) | 27 (25; 30) | 27 (24; 29) | 27 (25; 30) | 0.3567◊ | |
| BMI D30 (median [IQR]) | 27 (25; 30) | 27 (25; 30) | 26.5 (24; 29) | 27 (25; 30) | 0.1906◊ | 0.0001⌂* |
| BMI M6 (median [IQR]) | 27 (25; 30) | 27.5 (25; 30) | 27 (24; 29) | 27 (25; 30) | 0.2135◊ | 0.3891⌂ |
| BMI A1 (median [IQR]) | 27 (25; 29.5) | 27 (25; 30) | 26 (24; 30) | 27 (25; 30) | 0.5458◊ | 0.1201⌂ |
| WHR D0 (median [IQR]) | 0.97 (0.93; 1.02) | 0.98 (0.94; 1.04) | 0.99 (0.95; 1.03) | 0.98 (0.94; 1.03) | 0.1514◊ | |
| WHR D30 (median [IQR]) | 0.98 (0.93; 1.03) | 0.98 (0.94; 1.03) | 0.99 (0.93; 1.03) | 0.98 (0.93; 1.03) | 0.7593◊ | 0.8432⌂ |
| WHR M6 (median [IQR]) | 0.98 (0.95; 1.02) | 0.97 (0.93; 1.02) | 1.00 (0.94; 1.03) | 0.98 (0.94; 1.02) | 0.2148◊ | 0.3083⌂ |
| WHR A1 (median [IQR]) | 0.99 (0.95; 1.02) | 0.98 (0.92; 1.03) | 0.99 (0.94; 1.03) | 0.98 (0.94; 1.02) | 0.6700◊ | 0.7363⌂ |
| Physical activity > 30 min/week D30 (% [n]) | ||||||
| None | 24.9% (46) | 26.2% (45) | 11.4% (12) | 22.3% (103) | 0.024 ⌐* | |
| 1–2 times | 22.7% (42) | 24.4% (42) | 21.9% (23) | 23.2% (107) | ||
| 3 times or more | 52.4% (97) | 49.4% (85) | 66.7% (70) | 54.5% (252) | ||
| Physical activity > 30 min/week M6 (% [n]) | ||||||
| None | 20.2% (36) | 25.6% (44) | 17.1% (18) | 21.5% (98) | 0.267⌐ | |
| 1–2 times | 25.8% (46) | 19.8% (34) | 20.0% (21) | 22.2% (101) | ||
| 3 times or more | 53.9% (96) | 54.7% (94) | 62.9% (66) | 56.3% (256) | ||
| Physical activity > 30 min/week A1 (% [n]) | ||||||
| None | 19.8% (34) | 23.2% (39) | 16.8% (17) | 20.4% (90) | 0.069⌐ | |
| 1–2 times | 33.1% (57) | 21.4% (36) | 22.8% (23) | 26.3% (116) | ||
| 3 times or more | 47.1% (81) | 55.4% (93) | 60.4% (61) | 53.3% (235) | ||
| Implementation of RFM at D30 (% [n]) | 74.4% (131) | 63.9% (108) | 68.0% (70) | 69.0% (309) | 0.104⌐ | |
| Implementation of RFM at M6 (% [n]) | 67.8% (116) | 53.7% (88) | 76.0% (79) | 64.5% (283) | < 0.001* | |
| Implementation of RFM at A1 (% [n]) | 64.7% (110) | 60.8% (101) | 76.8% (76) | 66.0% (287) | 0.027⌐* | |
BP: Blood pressure; BMI: Body mass index; WHR: Waist-hip ratio; all parameters of lipid metabolism and glucose in mg/dl; LDL: Low-density lipoprotein; HDL: High-density lipoprotein; RFM: Risk factor modification
*Significant
⌐Chi2-Test
◊Kruskal–Wallis test
⌂Wilcoxon signed-rank test
□Already published [23]; D30: Visit 30 days after screening visit; M6: Visit 6 months after screening visit; A1: Visit one year after screening visit
1testing CEA vs. CAS vs. BMT
2testing total value D30/M6/A1 vs. screening visit