Fig. 3.

Per-read performance of 5mC prediction at singletons and non-singletons. A F1 score across four datasets based on singleton and non-singleton classification using BS-seq as ground truth. Singletons are CpG sites that contain only one CpG up and down 10-base-pair (bp) regions; non-singletons are CpG sites with multiple CpG sites up and down 10-bp regions; concordant non-singletons are non-singletons where all CpGs with a 10-bp region have the same methylation state (i.e., all 100% or all 0% methylated); discordant non-singletons are non-singletons with both fully methylated and fully unmethylated CpGs. B ROC curves for the NA19240 dataset on singletons, non-singletons, concordant non-singletons, and discordant non-singletons