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. 2021 Oct 18;11:183. doi: 10.1186/s13578-021-00695-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Expression kinetics of selected genes during chondrogenesis. Expression of selected genes were quantified at different time point in 6 individual BM-MSC replicates during chondrogenesis in pellet conditions with (black line) or without TGFβ3 (hatched line) by RT-qPCR. Results are normalized to the expression at day 0 and expressed as the mean ± sem. Statistical significance of gene expression was indicated as *: p ≤ 0.05, **: p ≤ 0.01, ***: p ≤ 0.001 when compared to d0 and as ^$: p ≤ 0.05, ^$$: p ≤ 0.01 when samples cultured + or − TGFβ3 were compared. (HEYL: Hes Related Family BHLH Transcription Factor with YRPW Motif Like; PDK4 (Pyruvate Dehydrogenase Kinase 4); TIPARP (TCDD Inducible Poly(ADP-Ribose) Polymerase); NDN (Necdin, MAGE Family Member); ZFP36 (ZFP36 Ring Finger Protein); TNFAIP3 (TNF Alpha Induced Protein); KCNH1 (Potassium Voltage-Gated Channel Subfamily H Member 1); FKBP5 (FKBP Prolyl Isomerase 5); PRRG4 (Proline Rich And Gla Domain;) ETS2 (ETS Proto-Oncogene 2, Transcription Factor); JARID2 (Jumonji And AT-Rich Interaction Domain Containing 2); ITPR1 (Inositol 1,4,5-Trisphosphate Receptor Type 1); SLC19A2 (Solute Carrier Family 19 Member 2); NRG1 (Neuregulin 1); PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3); SPHK1 (Sphingosine Kinase 1); NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1); PLAUR (Plasminogen Activator, Urokinase Receptor); KCNE4 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 4); NFKBIA (NFKB Inhibitor Alpha); TSPAN2 (Tetraspanin 2); RASD2 (RASD Family Member 2); RGCC (Regulator of Cell Cycle); NMB (Neuromedin B))