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. 2021 Oct 18;11:183. doi: 10.1186/s13578-021-00695-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Relative gene expression during osteogenesis and adipogenesis. A Adipogenic differentiation of BM-MSCs characterized by increased expression of peroxysome proliferator-activated receptor (PPAR)-γ, Fatty Acid Binding Protein (FABP4) and lipoprotein lipase (LPL) and by staining of lipid droplets by Red Oil O in differentiation versus proliferative conditions at day 21. B Relative expression of RGCC, TSPAN2 and NMB at different time points during adipogenic differentiation (black line) or in proliferative conditions (hatched line). C Osteogenic differentiation of BM-MSCs characterized by increased expression of RUNX2, osteocalcin (BGLAP), alkaline phosphatase (ALPL) and by Alizarin Red S staining in differentiation versus proliferative conditions at day 21. D Relative expression of RGCC, TSPAN2 and NMB at different time points during osteogenic differentiation (black line) or in proliferative conditions (hatched line). Results are expressed as mean fold change ± sem and statistical significance was indicated as *: p ≤ 0.05, **: p ≤ 0.01, ***: p ≤ 0.001 when samples were compared to day 0 and as ^$: p ≤ 0.05, ^$$: p ≤ 0.01 when proliferation and differentiation conditions were compared (n = 6 biological replicates)