FIGURE 4.

WTAP is highly expressed in renal cell carcinoma (RCC). (A) The UALCAN database indicated that WTAP expression was significantly higher in RCC than in normal kidney tissues (p = 0.0032204). (B–E) The TCGA database showed differences in mRNA expression of WTAP in RCC among stages, grades, nodal metastasis status, and subtypes. (F) At the mRNA level, the expression of WTAP was markedly increased in RCC cells. (G) Western blots indicated the upregulated expression of WTAP in RCC cell lines compared to HK‐2 cells. GAPDH was used for normalization. (H) Kaplan–Meier survival analysis indicated that patients with high WTAP expression had a lower survival time than those with low RCC expression (p = 0.0267). *p < 0.05