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. 2021 Oct 5;12:743086. doi: 10.3389/fphar.2021.743086

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Copyright © 2021 Li, Mao, Wang, Liu, Wang, Li, Li, Zhang and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of BHGZD on the severity of arthritis in AIA-M rats of different groups. (A) Macroscopic performances of arthritis; (B) infrared thermography; (C) weight; (D) arthritis incidence; (E) arthritis scores; (F) the diameter of the limb; (G) articular temperature; (H) the thymus index; (I) the spleen index; (J) mechanically induced hyperalgesia; (K) acetone-induced hyperalgesia; (L) thermally induced hyperalgesia. Data are expressed as the mean ± S.D. *, **, and ***, p < 0.05, p < 0.01, and p < 0.001, respectively, in comparison with the normal control group; #, ##, and ###, p < 0.05, p < 0.01, and p < 0.001, respectively, in comparison with the AIA-M group.