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. 2021 Oct 5;12:743086. doi: 10.3389/fphar.2021.743086

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Copyright © 2021 Li, Mao, Wang, Liu, Wang, Li, Li, Zhang and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BHGZD inhibits LPS/ATP–induced pyroptosis in both Raw264.7 macrophage and MH7A cells. (A ∼ B) Flow cytometry analysis for Annexin V/PI staining in Raw264.7 macrophage cells. (C) Representative images of FLICA caspase-1 that binds only to activated caspase-1 (scale bar represents 10 μm; FAM-FLICA green, PI red, Hoechst blue). (D) Representative phase-contrast images of MH7A cells (scale bar represents 50 μm). Arrows indicate cells undergoing pyroptosis (swollen cells). (E) TUNEL staining of MH7A cells (scale bar represents 50 μm; TUNEL red, Hoechst blue). ***, p < 0.001, in comparison with the normal control group; # and ##, p < 0.05 and p < 0.01, respectively, in comparison with the LPS/ATP–induced model.