Table 2.
Multivariable analyses for aGVHD grade 2 to 4 and Rel/prog and association with each HLA-DPB1 matching model
| HLA-DPB1 matching | Categories | aGVHD grade 2 to 4 (N = 860, events = 297)* | Rel/prog (N = 837, events = 302)*† | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Events/n | HR | 95% CI | P | Events/n | HR | 95% CI | P | ||||
| Classical matching.1 | Matched | 67/250 | 1.00 | — | 96/237 | 1.00 | — | ||||
| 1 mismatch | 145/398 | 1.40 | 1.05 | 1.87 | .02 | 145/393 | 0.81 | 0.62 | 1.05 | .11 | |
| 2 mismatch | 85/212 | 1.52 | 1.10 | 2.10 | .01 | 61/207 | 0.62 | 0.45 | 0.86 | .004 | |
| Classical matching.2 | matched | 67/250 | 1.00 | — | 96/237 | 1.00 | — | ||||
| 1 mismatch bidirectional | 101/254 | 1.60 | 1.17 | 2.19 | .003 | 96/248 | 0.84 | 0.63 | 1.11 | .22 | |
| 1 mismatch GvH | 23/79 | 1.01 | 0.63 | 1.63 | .96 | 23/76 | 0.66 | 0.42 | 1.05 | .08 | |
| 1 mismatch HvG | 21/65 | 1.20 | 0.73 | 1.95 | .48 | 26/69 | 0.88 | 0.57 | 1.36 | .56 | |
| 2 mismatch | 85/212 | 1.52 | 1.10 | 2.10 | .01 | 61/207 | 0.62 | 0.45 | 0.86 | .004 | |
| TCE3.1 | Matched | 67/250 | 1.00 | — | 96/237 | 1.00 | — | ||||
| Nonpermissive | 115/288 | 1.54 | 1.13 | 2.09 | .006 | 91/284 | 0.68 | 0.51 | 0.91 | .01 | |
| Permissive | 115/322 | 1.36 | 1.00 | 1.84 | .05 | 115/316 | 0.80 | 0.61 | 1.05 | .10 | |
| TCE3.2 | Matched | 67/250 | 1.00 | — | 96/237 | 1.00 | — | ||||
| Nonpermissive GvH | 71/165 | 1.76 | 1.25 | 2.46 | .001 | 50/163 | 0.67 | 0.48 | 0.95 | .02 | |
| Nonpermissive HvG | 44/123 | 1.28 | 0.87 | 1.88 | .21 | 41/121 | 0.70 | 0.48 | 1.01 | .06 | |
| Permissive | 115/322 | 1.36 | 1.00 | 1.84 | .05 | 115/316 | 0.80 | 0.61 | 1.05 | .10 | |
| TCE4.1 | Matched | 67/250 | 1.00 | — | 96/237 | 1.00 | — | ||||
| Nonpermissive | 156/403 | 1.48 | 1.11 | 1.97 | .008 | 127/403 | 0.66 | 0.51 | 0.86 | .002 | |
| Permissive | 74/207 | 1.37 | 0.99 | 1.91 | .06 | 79/197 | 0.92 | 0.68 | 1.24 | .58 | |
| TCE4.2 | Matched | 67/250 | 1.00 | — | 96/237 | 1.00 | — | ||||
| Nonpermissive GvH | 87/228 | 1.45 | 1.05 | 1.99 | .02 | 69/230 | 0.63 | 0.46 | 0.86 | .003 | |
| Nonpermissive HvG | 69/175 | 1.52 | 1.08 | 2.13 | .02 | 58/173 | 0.71 | 0.51 | 0.98 | .04 | |
| Permissive | 74/207 | 1.37 | 0.99 | 1.91 | .06 | 79/197 | 0.92 | 0.68 | 1.24 | .58 | |
| Expression | Matched | 67/250 | 1.00 | — | 96/237 | 1.00 | — | ||||
| R-high, D-high | 24/47 | 2.84 | 1.76 | 4.58 | <.001 | 13/44 | 0.74 | 0.41 | 1.33 | .31 | |
| R-high, D-low | 47/121 | 1.56 | 1.07 | 2.27 | .02 | 31/116 | 0.61 | 0.41 | 0.92 | .02 | |
| R-low, D-high | 13/57 | 0.81 | 0.45 | 1.48 | .50 | 33/59 | 1.11 | 0.75 | 1.66 | .60 | |
| R-low, D-low | 40/106 | 1.38 | 0.93 | 2.05 | .11 | 39/102 | 0.76 | 0.52 | 1.10 | .15 | |
| PIRCHE I | 0 | 137/438 | 1.00 | — | 161/424 | 1.00 | — | ||||
| 1-3 | 116/297 | 1.26 | 0.98 | 1.62 | .07 | 99/284 | 0.83 | 0.64 | 1.06 | .13 | |
| >3 | 44/125 | 1.17 | 0.83 | 1.66 | .37 | 42/129 | 0.84 | 0.60 | 1.18 | .32 | |
| PIRCHE II | 0 | 110/389 | 1.00 | — | 151/378 | 1.00 | — | ||||
| 1-10 | 97/250 | 1.51 | 1.15 | 1.99 | .003 | 83/236 | 0.76 | 0.58 | 0.99 | .04 | |
| >10 | 90/221 | 1.46 | 1.09 | 1.95 | .01 | 68/223 | 0.73 | 0.55 | 0.97 | .03 | |
.05 > P ≥ .01 are shown in bold and italic; P < 0.01 are shown in bold, italic, and underlined. Significant covariables retained for aGVHD: HLA-DRB3/4/5 matching, graft manipulation, and transplant center.
Significant covariables retained for relapse/progression (Rel/prog): European Society for Blood and Marrow Transplantation risk score, graft manipulation, and transplant center. CI, confidence interval; D, donor; Events, number of events in the risk category for the specified outcome; n, number of patients in the risk category for the specified outcome; R, recipient.
The number of patients/events for the regressions with expression is N = 579/191 and 558/212 for aGVHD ≥2 and Rel/prog, respectively.
Patients with nonmalignant disorder are excluded from analyses on relapse.