Table 1.
Baseline characteristics of the Lifelines cohort and prevalence of cytopenias according to different proposed cutoff criteria.
| n | Total cohort | <60 y old | ≥60 y old | |
|---|---|---|---|---|
| No. of individuals | 152180 | 152180 | 129728 | 22452 |
| Males | 152180 | 63130 (41.5) | 52886 (40.8) | 10244 (45.6) |
| Age, median (range), y | 152180 | 44 (18-93) | 42 (18-59) | 65 (60-93) |
| Hemoglobin level, mean (SD), g/dL | 147170 | 14.14 (1.27) | 14.12 (1.29) | 14.24 (1.16) |
| Platelet count, mean (SD), ×109/L | 147074 | 249.9 (56.6) | 251.7 (56.4) | 239.7 (56.8) |
| White blood cell count, mean (SD), ×109/L | 147171 | 6.10 (1.79) | 6.13 (1.73) | 5.92 (2.11) |
| Neutrophil count, mean (SD), ×109/L | 144676 | 3.33 (1.23) | 3.36 (1.25) | 3.15 (1.10) |
| Anemia (<12.0 g/dL [women] or <13.0 g/dL [men])* | 147170 | 6159 (4.2) | 5403 (4.2) | 756 (3.4) |
| Moderate (<11.0 g/dL)† | 147170 | 1272 (0.9) | 1186 (0.9) | 86 (0.4) |
| Severe (<10.0 g/dL)‡,§ | 147170 | 442 (0.3) | 419 (0.3) | 23 (0.1) |
| Thrombocytopenia (<150 × 109/L)* | 147074 | 2408 (1.6) | 1777 (1.4) | 631 (2.8) |
| Moderate (<100 × 109/L)†,§ | 147074 | 153 (0.1) | 117 (0.09) | 36 (0.2) |
| Neutropenia (<1.8 × 109/L)*,‡ | 144676 | 6925 (4.8) | 5643 (4.3) | 1282 (5.7) |
| Moderate (<1.5 × 109/L)† | 144676 | 2050 (1.4) | 1644 (1.3) | 406 (1.8) |
| Severe (<0.8 × 109/L)§ | 144676 | 30 (0.02) | 27 (0.02) | 3 (0.01) |
Unless otherwise noted, data are n (%).
SD, standard deviation.
*
Generally accepted reference values, argued for by Greenberg et al to define cytopenias in MDSs11 and used to define ICUS in 2017.10
†
Used to define ICUS in 2007.13
‡
WHO criteria to define cytopenias in MDS.14
§
Alternative criteria to define cytopenias relevant for prognosis in MDS (IPSS-R).12