Table 3.

Subdistribution hazard ratios for death from hematological malignancies according to the presence of unilineage or multilineage cytopenias in the entire evaluable Lifelines cohort (n = 152 096).

	n*	Unadjusted HR (95% CI)	P	Adjusted HR (95% CI)†	P
Anemia	6156	4.71 (2.83-7.86)	<.001	4.55 (2.67-7.73)	<.001
Thrombocytopenia	2408	7.32 (3.91-13.70)	<.001	3.71 (1.90-7.27)	<.001
Neutropenia	6925	3.41 (1.90-6.14)	<.001	3.41 (1.87-6.20)	<.001
>1 cytopenia	861	18.20 (9.13-36.40)	<.001	14.37 (7.00-29.47)	<.001

Estimates were obtained by competing risk regression, according to the method of Fine and Gray, taking into account death from other causes as a competing risk. Individuals with an absence of the respective cytopenia or a multilineage cytopenia were used as the reference. Anemia: hemoglobin concentration <13.0 g/dL in men and <12.0 g/dL in women; thrombocytopenia: platelet count <150 × 10⁹/L; neutropenia: neutrophil count <1.8 × 10⁹/L.

^*Number of individuals with the respective cytopenia evaluable for cause of death.

^†The multivariable model included age and sex as covariates.