Table 2.

MND ADA vector integration site data

Patient	Time (mo)	VCN	Unique integrants	Chao 1*	Shannon†	>20% clones‡	Near proto-oncogene‡
401	24	0.010	9	12	1.98	Yes (1)	No
	82	0.105	27	50	2.27	No	No
402	21	0. 742	729	1,909	5.89	No	MECOM
	120	0.476	430	1,100	5.45	No	MECOM
403	30	0.195	26	33	2.54	Yes	MECOM
	118	0.545	47	72	2.51	No	MECOM
404	24	0.686	1725	8750	7.22	No	No
	54	0.540	353	1573	5.72	No	No
405	42	0.490	67	118	3.86	No	No
	60	0.496	225	675	5.03	No	No
406	24	0.172	74	133	4.07	No	No
	84	0.483	196	384	4.58	No	No
407	24	0.401	25	28	1.94	Yes (3)	No
	96	0.519	50	221	2.35	Yes (1)	No
408	42	1.240	114	465	4.65	No	MECOM
	84	1.280	373	1113	5.82	No	No
409	36	0.287	73	191	4.02	No	No
	84	0.627	247	701	4.59	No	No
410	24	1.130	342	2220	5.79	No	No
	72	0.91	442	2068	5.98	No	No

^*Chao 1: lower bound of total unique integrants per sample.

^†Shannon diversity index: measure of diversity accounting for abundance and evens of integration events; polyclonal samples have high Shannon index.

^‡Present at ≥1% of total integrants. See supplemental Table 1 for gene details. The supplemental Figure 4 shows a further analysis of all detected MECOM integrants over time.