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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Neuropharmacology. 2021 Sep 22;199:108805. doi: 10.1016/j.neuropharm.2021.108805

Figure 1. GRIN variants are associated with various neurologic disorders.

Figure 1.

A), Architecture and domain organization for the NMDAR. B), Summary of NMDAR variants in different GRIN subunits and domains. C), Summary of GRIN variant-associated phenotypes. ATD: amino terminal domain, ABD: agonist binding domain, TMD-link: transmembrane domains (M1-4) and linker regions, CTD: intracellular carboxy-terminal domain. ASD: Autism Spectrum Disorder, CVI: cortical visual impairment, Epi: epilepsy/seizures, Hypo: hypotonia, ID/DD: intellectual disability/developmental delay; LP/SP: language/speech problems; MD: movement disorders; Sleep: sleep problems. Many individuals showed multiple phenotypes, which are only a snapshot of the current literature, which is disproportionally weighted by different diagnostic approaches and ascertainment.