. Author manuscript; available in PMC: 2021 Oct 19.

Published in final edited form as: Nat Rev Drug Discov. 2021 Feb 15;20(4):287–307. doi: 10.1038/s41573-020-00109-w

Table 3 |.

Clinical trials involving behavioural and environmental modifications

Modifications	Disease indications	Parameters	Examples
Light therapy	Stroke, ageing, Parkinson disease, Alzheimer disease, mood disorders, metabolic disease, night shift, PTSD, traumatic brain injury, sepsis, cancer-related fatigues	Circadian rhythms in sleep and blood parameters, cognition, activity, fatigue, depression and PTSD scores, inflammation markers	NCT02186392
			NCT02502045
			NCT02769858
			NCT01855126
			NCT01048294
			NCT01747811
Time-restricted feeding	Obesity, metabolic syndrome, shiftwork	Body weight, metabolic homeostasis, cardiometabolic parameters	NCT02204735
Time-restricted feeding	Obesity, metabolic syndrome, shiftwork		NCT03527290
Sleep intervention	Night-shift work, traumatic brain injury	Sleep quality	NCT02838082
Sleep intervention	Night-shift work, traumatic brain injury	Sleep quality	NCT02609373
Scheduled activity	Diabetes, Alzheimer disease	Sleep, glucose homeostasis	NCT03553524
Scheduled activity	Diabetes, Alzheimer disease	Sleep, glucose homeostasis	NCT01920672
Combination: including sleep, light, exercise and lithium	Night-shift work, HIV-related fatigue, mood disorders, ICU stay	Circadian phase, sleep, metabolic parameters, mood rating, clock gene expression	NCT01284140
			NCT01767181
			NCT02126007
			NCT01799733
			NCT03405493
			NCT01431573

ICU, intensive care unit; PTSD, post-traumatic stress disorder.