Table 1.

Three of the randomized control trials for patients with advanced prostate cancer

Study	Criteria for high-volume disease	Reference	Patients from our study who fit the criteria, n (%)
CHAARTED	Presence of visceral metastasis and/or at least 4 bone metastases with at least 1 beyond the pelvis or vertebral column	[10]	47 (9)
STAMPEDE	Either metastatic or node-positive or high-risk locally advanced disease with at least 2 of stage T3/T4, PSA >40 ng/ml or Gleason score 8–10	[10,11]	158 (30.3)
LATTITUDE	Newly diagnosed hormone-sensitive metastatic prostate cancer with at least two of: Gleason score ≥8, ≥3 bone lesions or measurable visceral lesions	[12]	27 (5.2)

PSA: Prostate-specific antigen