TABLE 1.
Baseline characteristics for SAD and MAD phases
| Parameter | SAD phase |
MAD phase |
||
|---|---|---|---|---|
| Placebo (n = 14) | SPR720 (n = 42) | Placebo (n = 10) | SPR720 (n = 30) | |
| Mean age (yr) ± SDa | 40.1 ± 14.6 | 39.0 ± 16.0a | 32.9 ± 12.1 | 35.4 ± 9.5 |
| No. male (%) | 12 (85.7) | 36 (85.7) | 9 (90.0) | 27 (90.0) |
| Mean body wt (kg) ± SD | 81.8 ± 9.4 | 80.6 ± 10.5 | 79.0 ± 9.7 | 78.4 ± 9.6 |
| Mean BMIb (kg/m2) ± SD | 26.5 ± 2.7 | 26.5 ± 2.8 | 25.8 ± 3.4 | 25.2 ± 3.0 |
| No. (%) Caucasian | 14 (100.0) | 42 (100.0) | 8 (80.0) | 30 (100.0) |
a
The mean age ± the SD for the elderly cohort was 67.8 ± 2.6 years.
b
BMI, body mass index.