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. 2021 Oct 14;14:1481–1496. doi: 10.2147/CCID.S334527

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© 2021 Shi et al.

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Protective and reparative effects of GLP1, GLP1I, and GLP1II treated on H₂O₂-induced oxidative damaged HSFs. VC was considered as a positive control. (A1–E1) shows the protective effects of GLP1, GLP1I, and GLP1II. HSFs were pretreated respectively with GLP1, GLP1I, and GLP1II at the concentration of 1.25 g·L⁻¹ followed by 100 μmol·L⁻¹ H₂O₂ for 2 h. (A2–E2) shows the reparative effects of GLP1, GLP1I, and GLP1II. HSFs were pretreated with 100 μmol·L-1 H₂O₂ for 2 h, followed by GLP1, GLP1I, and GLP1II at the concentration of 1.25 g·L⁻¹, respectively. (A1 and A2) catalase activities; (B1 and B2), GSH-Px activities; (C1 and C2) SOD activities; (D1 and D2) MDA contents; (E1 and E2) ROS levels represented by fluorescence intensity. Results are expressed as the mean ± SD (n = 3). The Student’s t-test was performed to determine statistical significance (**P < 0.01, ***P < 0.001, versus the control group; ^###P < 0.001, versus the model group).