FIG 4.

Enrichment and depletion of insertions as a function of nucleotides surrounding TA sites for the 14 libraries of H37Rv in vitro. The mean LFC [log fold change: log₂(observed_count/local_mean)] of sites with each filtered nucleotide at every position in a 20-bp window of the TA site in the H37Rv data set is visualized here. The heatmap is centered at the median of mean LFCs. Nucleotides colored green at certain positions are enriched (have higher than average insertion counts), while those colored purple are depleted (relative to the local average nucleotide content).