FIG 3.

Stage-dependent expression. Uninformative antigens were filtered as stated in Materials and Methods. Asterisks indicate significance. (a) Distribution of antigen expression as a function of the clinical stage. Patients were filtered for positivity in the case definition. Only patients who did not receive antibiotics prior to the assay are shown. Kruskal-Wallis test followed by post hoc Holm’s-corrected Dunn’s test. For significant comparisons, indicated by asterisks (P ≤ 0.05), effect size is indicated by η², based on Kruskal-Wallis’ H statistic (see Materials and Methods, “Statistical analysis”). (b) Scatterplot of effect size versus negative log of P value, obtained as described in panel a. Effect sizes that were considered large (η² ≥ 0.14) were labeled. Asterisks indicate statistical significance according to the respective P value (*, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001).