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. 2021 Oct 8;6(19):e145172. doi: 10.1172/jci.insight.145172

Figure 4. The silencing of PRR11 expression inhibited the migration and decreased the EMT of ccRCC cells.

Figure 4

(A–D) Transwell migration assays were used to evaluate the migration of PRR11 knockdown and PRR11-overexpressing ccRCC cells, and the relative number of migrated cells was statistically analyzed (n = 3). Scale bar: 150 μm. (E–L) Wound healing assays were used to evaluate the migration of PRR11 knockdown and PRR11-overexpressing ccRCC cells, and the relative number of migrated cells was statistically analyzed (n = 3). Scale bar: 150 μm. (M and N) Western blotting analysis of EMT-related protein expression in PRR11-silenced or PRR11-overexpressing ccRCC cells (n = 3). The data are shown as mean ± SD. One-way ANOVA with Dunnett’s multiple comparisons test (B, F, and J) and 2-tailed t test (D, H, and L) analyses were performed. NS, *P < 0.05, **P < 0.01, ***P < 0.001. PRR11, proline rich 11; EMT, epithelial-mesenchymal transition; ccRCC, clear cell renal cell carcinoma.