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. 2021 Oct 8;6(19):e151777. doi: 10.1172/jci.insight.151777

Figure 4. Peripheral mucin mRNA expression levels as discriminators for critical COVID-19, mild COVID-19, and mild non–COVID-19.

Figure 4

(A) 3D PCA plot based on mucin mRNA expression values, age, and sex from critically ill COVID-19 patients (n = 50), mild COVID-19 patients (n = 35), and mild non–COVID-19 patients (n = 30). PC1 explains 28.7% of the variation; PC2 explains 17.8% of the variation. (B) sPLS-DA plot based on mucin mRNA expression values, age, and sex as major predictors for critical COVID-19 (n = 50), mild COVID-19 (n = 35), and mild non–COVID-19 (n = 30). (C) Contribution plot indicating the main predictor variables contributing to component 1 of the sPLS-DA plot that discriminate between critical COVID-19 (n = 50; i.e., age and MUC1 mRNA expression), mild COVID-19 (n = 35; i.e., MUC2, MUC20, and MUC21 mRNA expression), and mild non–COVID-19 (n = 30; i.e., MUC4, MUC6, and MUC16 mRNA expression and sex) patients.