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. 2021 Oct 8;6(19):e148887. doi: 10.1172/jci.insight.148887

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© 2021 Min et al.

This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A–C) IgH-CDR3 profiles of the BM IgM isotype. (A) CDR3 length distribution and average CDR3 length (mean ± SD) of an HC and the patient. (B) Average length of the D_H segments. Mean ± SD is shown. (C) Reduced N nucleotide addition in the patient (mean ± SD). (D and E) IgH-CDR3 profiles of peripheral IgM isotype. (D) CDR3 length distribution and average CDR3 length (mean ± SD). (E) Average length of the D_H segments. Mean ± SD is shown. Statistical analyses were performed using Student’s t test. *P < 0.05; **P < 0.01; ****P < 0.0001.