Fig 2.

(A) Estimated cumulative direct costs and indirect costs of EL versus SQ. (B) Net economic benefit of EL versus SQ including direct and indirect costs. For the net economic benefit of EL, 3 economic perspectives were used: Perspective A–Direct costs only with no integration of testing. Perspective B–Direct costs (no integration of testing) and productivity gains. Perspective C–Partially integrated direct costs and productivity gains. All costs are in 2018 US$ and discounted at 3.5% per annum; healthcare costs were applied to all liver disease states pre- and post-cure; staffing costs were applied to all testing and treatment interactions; one-third of initial screening was assumed to not incur staffing costs and had reduced HCV RNA testing kit cost in the EL scenario with economic perspective C. The solid line and shading indicate the median and 95% UIs across 1,151 model fits. EL, elimination; HCV, hepatitis C virus; SQ, status quo; UI, uncertainty interval.