Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The interactions of autophagy with NPM1-mutated (mt-NPM1) AML. NPM1 interacts with PML in the nucleus. Mutated NPM1 abnormally localizes at the cytoplasm, leading to PML cytoplasmic delocalization and stabilization. Aberrantly-accumulated PML enhances autophagy levels via AKT and promotes leukemic cell survival and the progression of AML with NPM1 mutations. Pharmacological repression of autophagy and/or PML may be a promising approach for treating NPM1-mutated AML patients
