Figure 3.
The associations between autophagy with AML depending on TP53 status. (A) for AML with wild-type TP53, autophagy suppression activates TP53 to increase the efficacy of promoting apoptosis. (B) for AML with TP53 mutations (mt-TP53), HSP90 inhibitor 17-AAG induces macroautophagy to promote the autophagic degradation of TP53R248Q. When metabolic stress suppresses macroautophagy, 17-AAG can mediate the CMA-dependent degradation of TP53R248Q in AML cells. (C) for AML with wild-type TP53 under cellular stresses, activated TP53 by cellular stress promotes autophagy induction to induce cell death