Figure 5.

Interactions between autophagy and fusion oncoproteins caused by chromosome rearrangements in AML. (A) The differentiation-inducing agent ATRA can enhance autophagy through MTORC1 repression, and stimulated autophagy activity promotes PML-RARA autophagic degradation via a variety of mechanisms. (B) The stability of KMT2A-MLLT3 and KMT2A-AFF1 fusion proteins is maintained by LAMP5 through the suppression of selective autophagic degradation, and DOT1L mediates the activation of LAMP5. LAMP5 knockdown can be applied to synergize with DOT1L inhibitors to promote KMT2A fusion eradication for KMT2A treatment