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Disturbed folliculogenesis in PCOS and its connection with autophagy. Different autophagic pathways are involved in altered folliculogenesis in the PCOS ovary. An increase in ROS promotes autophagy and the formation of cysts. An increase in TUG1 expression suppresses autophagy by obstructing the MAPK/ERK pathway and supports antral follicle survival. Activation of the MTOR pathway inhibits autophagy and promotes aberrant growth of follicles
