Table 3.
Enrichment of PFAM protein domains in the pool of genes displaying non-synonymous mutations in the M. abscessus isolates from patient C according to STRING network analysis
| PFAM Protein domain and term description | Matching proteins1 | False discovery rate |
|---|---|---|
| PF00550 Phosphopantetheine attachment site | MAB_0939 (eryA), MAB_2255, MAB_2256, MAB_4690c (lgr_C2), MAB_4099c (lgrC_1), MAB_4098c (lgrD_2) | 7.23 x 10−5 |
| PF00668 Condensation domain | MAB_2255, MAB_4098c (lgrD_2), MAB_4099c (lgrC_1), MAB_4690c (lgr_C2) | 0.00093 |
| PF13193 AMP-binding enzyme C-terminal domain | MAB_2255, MAB_4098c (lgrD_2), MAB_4099c (lgrC_1), MAB_4690c (lgr_C2) | 0.0153 |
| PF04602 Mycobacterial cell wall arabinan synthesis protein | MAB_0186c (embA), MAB_0189c (embC) | 0.0164 |
| PF14896 EmbC C-terminal domain | MAB_0186c (embA), MAB_0189c (embC) | 0.0164 |
| PF00732 GMC oxidoreductase | MAB_0816 (betA_1), MAB_3719c (choD) | 0.0227 |
| PF05199 GMC oxidoreductase | MAB_0816 (betA_1), MAB_3719c (choD) | 0.0227 |
| PF00501 AMP-binding enzyme | MAB_2255, MAB_4098c (lgrD_2), MAB_4099c (lgrC_1), MAB_4690c (lgr_C2) | 0.0264 |
| PF16197 Ketoacyl-synthetase C-terminal extension | MAB_0939 (eryA), MAB_2256 | 0.0264 |
| PF00698 Acyl transferase domain | MAB_0939 (eryA), MAB_2256 | 0.0488 |
1Locus tags (gene names) of the homologs in the reference strain ATCC 19977.