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. 2021 Oct 8;10:e69480. doi: 10.7554/eLife.69480

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© 2021, Hwang et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 7. — (A) Voxel-wise kernel density plot of thalamocortical functional connectivity weight for each cortical network. Voxels in the multi-domain lesion site exhibit stronger functional connectivity with the cingulo-opercular (CO), limbic (Lm), frontoparietal (FP), and default mode (DMN) networks. Weaker connectivity with visual (V), somatomotor (SM), and dorsal attention (DA) networks. (B) Voxel-wise kernel density plot of thalamocortical functional connectivity weight with cortical regions identified via Neurosynth meta-analyses. For both (A) and (B), higher weight ratio indicates functional specificity, suggesting that voxel is selectively interacting with a specific cortical system. (C) The multi-domain lesion site overlaps with higher-order thalamic nuclei, including the anterior (AN), ventromedial (VM), mediodorsal (MD), intra-laminar (IL), ventro-anterior (VA), and ventrolateral (VL) nuclei.