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Methods for enhancing the sensitivity of tumor cells to ionizing radiation by modulating the p53-family proteins. (A) – Modulation of p53 by low-molecular-weight-stabilizing molecules and chaperones. (B) – Regulation of p73 by acting on Snail family proteins and E3 ubiquitin ligase (MDM2, ITCH). (C) – The impact on p63 isoforms via Pt-containing compounds, low-molecular-weight stabilizers and ubiquitin ligase activity (MDM2, FBXW7). See explanation in the text
