Table 1.

Association of the selected single nucleotide polymorphisms and SARS-CoV-2 infection

Chr	SNP ID	Risk allele	Mapped genes	COVID-19 patients (n = 475) vs. controls (n = 2217)			Hospitalized COVID-19 patients (n = 146) vs. controls (n = 2217)
Chr	SNP ID	Risk allele	Mapped genes	P/P_adj	AF (case/ctrl)	OR (95% CI)	P/P_adj	AF (case/ctrl)	OR(95% CI)	GWAS catalog OR (95% CI)
3	rs71325088	C	SLC6A20, LZTFL1	0.0007/0.007	0.13/0.09	1.46 (1.17–1.81)	0.00001/0.0001	0.16/0.09	2.10 (1.50–2.92)	1.9^a (1.73–2.0)
3	rs11385942	A	LZTFL1	0.0005/0.005	0.13/0.09	1.47 (1.18–1.82)	0.000006/0.00006	0.16/0.09	2.14 (1.54–2.99)	2.11^b (1.70–2.61)
3	rs73064425	T	AC099782.3, LZTFL1	0.0008/0.007	0.13/0.09	1.45 (1.17–1.80)	0.00001/0.00009	0.16/0.09	2.13 (1.52–2.97)	1.7^a NR
6	rs143334143	A	CCHCR1	0.7/1	0.09/0.09	0.94 (0.73–1.22)	0.4/1	0.10/0.09	1.18 (0.78–1.80)	1.3^a (1.27–1.48)
9	rs657152	A	ABO	0.1/0.891	0.47/0.44	1.13 (0.98–1.31)	0.1/1	0.48/0.44	1.22 (0.95–1.55)	1.32^b (1.20–1.47)
12	rs6489867	C	OAS1, AC004551.1	0.9/1	0.30/0.31	0.99 (0.85–1.16)	0.7/1	0.29/0.31	0.96 (0.73–1.25)	1.2^a (1.14–1.25)
19	rs2109069	A	DPP9	0.01/0.115	0.30/0.27	1.22 (1.04–1.44)	0.1/1	0.30/0.27	1.22 (0.94–1.59)	1.2^a (1.19–1.31)
19	rs11085727	T	TYK2	0.03/0.235	0.31/0.28	1.20 (1.02–1.40)	0.1/1	0.32/0.28	1.23 (0.95–1.60)	1.2^a (1.18–1.31)
21	rs13050728	T	AP000295.1, IFNAR2	0.6/1	0.39/0.38	1.04 (0.90–1.21)	0.06/1	0.43/0.38	1.28 (0.99–1.64)	1.2^a (1.16–1.28)

Bold represents the significant P-values after Bonferroni correction

^aFrom Pairo-Castineira et al. 2021

^bFrom The Severe COVID-19 GWAS Group 2020.

Bold represent the significant P-values. Chr, Chromosome number; SNP, Single nucleotide polymorphism; AF, Allele frequency; P_adj, Bonferroni adjusted P-value; ctrl, controls; OR, Odds ratio; CI, Confidence interval; NR, not recorded