Table 4.
Correlation of methylation with metabolic risk factors and relative markers gene expression in obese subjects
| Variable | Leptin methylation | Leptin unmethylation | |||
|---|---|---|---|---|---|
|
|
|
||||
| Correlation (r) | P | Correlation (r) | P | ||
| Age | 0.560 | < 0.001† | 0.171 | 0.357 | |
| Sex | –0.267 | 0.213 | –0.097 | 0.584 | |
| Height | –0.287 | 0.128 | 0.169 | 0.506 | |
| Weight | –0.449 | 0.001* | 0.059 | 0.933 | |
| BMI | –0.329 | 0.194 | –0.067 | 0.665 | |
| WC | –0.360 | 0.148 | –0.025 | 0.855 | |
| Cholesterol | –0.092 | 0.548 | 0.012 | 0.952 | |
| HDL cholesterol | 0.033 | 0.996 | 0.136 | 0.457 | |
| TG | 0.001 | 0.987 | –0.210 | 0.279 | |
| VLDL cholesterol | 0.001 | 0.987 | –0.210 | 0.279 | |
| LDL cholesterol | –0.119 | 0.482 | 0.029 | 0.897 | |
| Insulin | –0.063 | 0.927 | –0.160 | 0.390 | |
| Glucose | –0.174 | 0.358 | 0.046 | 0.813 | |
| HOMA-IR | –0.178 | 0.467 | –0.113 | 0.539 | |
| SBP | –0.273 | 0.170 | –0.177 | 0.403 | |
| DBP | –0.187 | 0.292 | –0.023 | 0.865 | |
| DNMT1 | 0.022 | 0.918 | 0.168 | 0.413 | |
| DNMT3b | 0.022 | 0.919 | 0.269 | 0.183 | |
| Leptin | –0.034 | 0.872 | –0.089 | 0.664 | |
*P< 0.01; †P< 0.001.
BMI, body mass index; WC, waist circumference; HDL, high-density lipoprotein; TG, triglyceride; VLDL, very low density lipoprotein; LDL, low-density lipoprotein; HOMA-IR, homeostatic model assessment for insulin resistance; SBP, systolic blood pressure; DBP, diastolic blood pressure; DNMT, DNA methyltransferase.