Table 2.

Potential therapies targeting CFH-mediated endothelial injury

Therapy	Method of Action	References
Haptoglobin	Endogenous scavenger of hemoglobin	(17, 21, 27, 66, 80, 82, 84–86, 88, 90)
Hemopexin	Endogenous scavenger of heme	(22, 80, 82, 84, 89, 90)
Plasma proteins (e.g. albumin)	Binds hemoglobin/heme	(69, 93)
Acetaminophen	Hemoprotein reductant	NCT04291508 (21, 25, 91, 92)
Ascorbate	Antioxidant	(34, 89)
NO donors [nitrite, nitrate, spermine NONOate (SPNO), S-nitrosoglutathione (GSNO)]	Delivers NO (increases bioavailability in hypoxic areas and reduces hemolysis)	(24, 94, 95)
Febuxostat	Xanthine oxidase inhibitor	(96)