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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Jun 15;13(6):e1732. doi: 10.1002/wnan.1732

FIGURE 2.

FIGURE 2

(a) Dialysis method. NPs are filled inside the dialysis bag placed into the outer medium reservoir. Samples are collected at specified intervals from outer compartment. (b) Reverse dialysis method. Opposite setup-NPs are placed in the outer compartment and the inner medium reservoir is sampled for drug release. (c) Side by side dialysis method. Equal volume donor and receiver compartments are separated by a dialysis membrane. Samples are taken from the receiver cell. (d) USP 4 (Flow Through Cell). Four different platforms comprising of dissolution platform, pump assembly, dissolution media (reservoir) and fraction collector. (e) Open Loop System. Fresh solvent from the reservoir (media selector) continuously replenishes through the flow cells to maintain infinite sink conditions. (f) Close Loop System. Small media volume is recirculated again and again from flow cell to reservoir. Sampling is done from the recirculating dissolution medium.