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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Trends Cell Biol. 2021 Jun 29;31(11):912–923. doi: 10.1016/j.tcb.2021.06.003

Figure 1: The first encounter of seipin and triacylglycerol (TG). Developmental pathway of an adipocyte.

Figure 1:

TG will form aggregates in membrane bilayers as its concentration increases. These aggregates will grow in size. Molecular dynamics simulations suggest that seipin promotes aggregation by binding to monomers (first arrow) [24, 25], while short-term incubation of cells with oleate first creates seipin-free aggregates which are then stabilized by seipin (second arrow) and develop further [34]. It is not clear whether one of these pathways is dominant in nature.