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Bivalirudin Dosing and Adjustment Protocol for Patients on ECMO
| Measured aPTT (s) | Dosing Adjustment Protocol |
|---|---|
| <45 | Increase infusion rate by 40% |
| 45-59 | Increase infusion rate by 20% |
| 60-80 | No change to infusion rate |
| 81-110 | Decrease infusion rate by 20% |
| >110 | Hold infusion for one hour, and then restart with previous rate decreased by 40% |
Abbreviation: aPTT, activated partial thromboplastin time.
