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. 2021 Oct 20;298(1):101290. doi: 10.1016/j.jbc.2021.101290

Figure 2.

Figure 2

Analysis of the binding of the different VHHs to the SARS-CoV-2 Nucleoprotein. A, binding of the different VHHs to SARS-CoV-2 recombinant Nucleoprotein determined by ELISA. N was coated at 1 μg/ml and VHHs at different concentrations were then added. B, real-time monitoring of the VHH/N interaction by SPR. The determined kinetic parameters of the VHHS are provided in Table 1. C, binding of the VHHs by ELISA on cell extracts. The VHH concentration leading to maximal difference obtained between infected and uninfected cell extracts are indicated by gray variations.