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IKK activation in response to pIC is PKR dependent. (A) Cell lines derived from Pkr+/+ and knockout mice with isogenic background were treated with pIC (100 μg/ml) for the indicated times. IKK kinase assay and immunoblotting were performed as described in the legend to Fig. 5A. (B) Pkr+/+ and Pkr0/0 cell lines were treated with TNF-α (5 ng/ml) and processed for IKK kinase assay and immunoblotting as described for panel A.
