Table 3.

The Association Between PNPLA2 Methylation and LC at Very Early Stage (Stage I)

CpG Sites	Controls (N = 187) Median (IQR)	LC Cases (N = 158) Median (IQR)	OR (95% CI)# per −10% Methylation	P-value#
PNPLA2_CpG_1	0.28 (0.17–0.40)	0.28 (0.18–0.40)	1.06 (0.88–1.29)	0.525
PNPLA2_CpG_2,3	0.17 (0.12–0.37)	0.18 (0.10–0.40)	0.96 (0.84–1.09)	0.507
PNPLA2_CpG_4	0.02 (0.02–0.04)	0.03 (0.02–0.04)	0.62 (0.23–1.67)	0.342
PNPLA2_CpG_5	0.04 (0.03–0.05)	0.04 (0.03–0.05)	0.87 (0.63–1.20)	0.394
PNPLA2_CpG_6	0.37 (0.32–0.43)	0.36 (0.27–0.48)	0.89 (0.76–1.03)	0.112
PNPLA2_CpG_7	0.23 (0.17–0.27)	0.22 (0.16–0.27)	1.08 (0.89–1.32)	0.432
PNPLA2_CpG_8,10	0.35 (0.31–0.38)	0.33 (0.28–0.38)	1.42 (1.05–1.93)	0.025
PNPLA2_CpG_9	0.28 (0.24–0.33)	0.29 (0.23–0.35)	0.80 (0.66–0.96)	0.017
PNPLA2_CpG_11,12	0.46 (0.38–0.53)	0.45 (0.35–0.51)	1.17 (0.97–1.42)	0.101
PNPLA2_CpG_13	0.15 (0.13–0.18)	0.15 (0.11–0.19)	0.84 (0.62–1.12)	0.238
PNPLA2_CpG_14,15,16,17	0.11 (0.08–0.13)	0.10 (0.07–0.14)	0.99 (0.57–1.73)	0.982
PNPLA2_CpG_18	0.12 (0.09–0.14)	0.11 (0.09–0.16)	0.91 (0.66–1.26)	0.578
PNPLA2_CpG_20,21	0.40 (0.34–0.45)	0.39 (0.30–0.47)	1.00 (0.81–1.23)	0.980

Notes: ^#Logistic regression, adjusted for age, gender and experimental batches. Significant P-values are in bold.

Abbreviations: LC, lung cancer; N, number; IQR, interquartile range; OR, odds ratio; CI, confidence interval.