Table 2.
Trm responses elicited by respiratory tract pathogens.
| Type | Pathogen | Tissue | Trm markers | Ref. |
|---|---|---|---|---|
| Virus | Influenza | LI |
Mouse CD8+CD69+/−CD103+/−(PD-1hi, IFITM3+, CD11a+, CD49a+, Ly6C−) Mouse CD4+CD69+(CD11a+, PD-1+, FR4lo/hi, PSGL1lo/hi) Human CD8+CD69+/−CD103+/−(HLA-DR+, NKG2A+, CD11a+) |
16,17,19,37,45,47,51,52,56,58,59,66,68,74,78–81,85–87,89,90,92–97,125,128,135,146 |
| LA |
Mouse CD8+CD69+CD103+(CD49a+) Human CD8+CD69+CD103+(CD49a+, CD101+, PD-1hi) Human CD4+CD69+CD103+/−(PD-1hi, CD49a+, CD101+) |
52,55–58,66,84,125 | ||
| Nasal | Mouse CD8+CD69+CD103+ | 19 | ||
| mLN | Mouse CD8+CD69+CD103+(Ly6C−) | 29,94 | ||
| Sendai | LA | Mouse CD8+ | 57 | |
| RSV | LA |
Mouse CD8+CD69+CD103+ Human CD8+CD69+CD103+ Human CD4+CD69+CD103+/− |
99,100,147 | |
| LI |
Mouse CD8+CD69+CD103+ Mouse CD4+CD69+CD103−(CD49d+CD11ahi) |
100,101 | ||
| SARS-CoV-2 | LA |
Human CD8+CD69+CD103+/−(HLA-DR+, PD-1+) Human CD4+CD69+CD103+/−(HLA-DR+, PD-1+) |
104–106 | |
| Vaccina virus | LI | Mouse CD8+CD69+CD103+/−(CXCR3lo/hi) | 82,126 | |
| LA | Mouse CD8+CXCR3hi | 126 | ||
| Bacteria | Streptococcus pneumoniae | LI | Mouse CD4+CD69+(CD11ahi) | 108,113 |
| Nasal | Mouse CD4+CD69+(CD11ahi) | 109 | ||
| Bordetella pertussis | LI | Mouse CD4+CD69+ | 110,148 | |
| Nasal | Mouse CD4+CD69+ | 109,110,148 | ||
| Klebsiella pneumoniae | LA | Mouse CD4+CD69+CD103− | 76 | |
| Mycobacterium tuberculosis | LI | Mouse CD4+CD69+(CXCR3hi, PD-1hi) | 111 | |
| LA | Human CD4+(CD45RO+) | 112 | ||
| Fungi | Aspergillus fumigatus | LI | Mouse CD4+CD69hiCD103lo | 149 |
| Parasite | Nippostrongylus brasiliensis | LI | Mouse CD4+(CD44+CD62L−) | 150 |
LI lung Interstitium, LA lung airway, mLn mediastinal lymph node. Text within brackets indicates additional markers expressed by respiratory tract Trm.