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. 2021 Oct 6;8:740526. doi: 10.3389/fcvm.2021.740526

Figure 3.

Figure 3

Ablation of LAPTM5 exacerbates pressure overload-induced remodeling. (A) Strategy of generating cardiac-specific conditional LAPTM5-KO mice. (B) Sanger sequencing results of heart tissue in WT and LAPTM5-KO mice. (C) Protein level of LAPTM5 in heart tissue in WT and LAPTM5-KO mice (n = 3). (D) Heart weight (HW) to body weight (BW) ratio, HW to tibia length (TL) ratio, lung weight (LW) to BW ratio in the indicated groups (n = 10). (E) Echocardiography results in each group (n = 10). LVEDd, left ventricular end diastolic diameter; LVESd, left ventricular end systolic diameter; EF, ejection fraction. (F) Representative image of H&E staining and the quantitative results (n = 6). (G) Representative image of PSR staining and the quantitative result (n = 6). (H,I) The mRNA levels of hypertrophic and fibrosis markers were detected by real-time PCR (n = 6) (*P < 0.05 vs. WT-Sham, #P < 0.05 vs. WT-AB).