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. 2021 Oct 6;15:674745. doi: 10.3389/fnins.2021.674745

FIGURE 2.

FIGURE 2

CI-994 restores recognition memory impaired by HAL in aged mice. Aged mice did not display a decrease in recognition memory tested by NOR (VEH-aged vs VEH-young, p = 0.2752), however, HAL induced a memory impairment (aged HAL vs aged VEH, p = 0.0042). CI-994 at 10 and 20 mg/kg improved the memory function in a dose dependent manner (aged CI-994 10mg/kg + HAL vs aged HAL, p = 0.0249; aged CI-994 20 mg/kg + HAL vs. aged HAL, p < 0.0001). No significant difference between 10 mg/kg CI-994 + HAL and 20 mg/kg CI-994 + HAL groups (p = 0.0576). Additionally, there was no difference between CI-994 alone and VEH groups in aged mice (aged CI-994 10 mg/kg vs. aged VEH, p > 0.9999; aged CI-994 20 mg/kg vs. aged VEH, p = 0.1109). Data represent mean ± SEM (n = 6–11/per group). *p < 0.05, **p < 0.01, ****p < 0.0001, NS, not significant.